Tirzepatide dual agonism: GIP + GLP-1 synergistic mechanism

MASHdoc_SA said:

Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…

This is my experience too, for whatever a second data point is worth. Posting only so the count is not one.

One thing that is still open after Dr.SleepRoch’s answer:

Which effects tachyphylax and which persist, because the answer explains why tolerability improves while the appetite effect keeps working?

HPLC_Greg said:

One practical note: write down what you did and when, before you need it.

I read this differently from HPLC_Greg, on substance rather than tone. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

HPLC_Greg said:

One practical note: write down what you did and when, before you need it.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.