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ForumsOral GLP-1 AgonistsGeneric oral semaglutide — looking for input Page 3

Generic oral semaglutide — looking for input

kate.chem Sun, Oct 6, 2024 at 5:52 PM 15 replies 1,965 viewsPage 3 of 3
carlos_SATX
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Oct 12, 2024 at 7:18 AM#11
newstart_MO said:
Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

Genuinely useful, thank you. I had the facts and not the framework. Sending this to two other people who asked me the same thing last week.

44 17james_edin, FranDenver, Dr.BariatricHTX and 41 others
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Dr.CardioMD
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Oct 12, 2024 at 12:02 PM#12

Clinical perspective, offered as context rather than as advice. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Last edited: Oct 12, 2024 at 6:02 PM
45 18Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 42 others
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Dr.RenalNash
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Oct 12, 2024 at 4:46 PM#13
sean_dublin said:
Steady state is the thing most people miss.

I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.

46 19Dr.NutriCornell, pam_stl, wei_SG and 43 others
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Dr.NateNeph
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Oct 12, 2024 at 9:30 PM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

47 20B12Beth, RickReta_CO, PharmHunterJen and 44 others
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mike_mod
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Oct 13, 2024 at 2:14 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Thread quality here is what the rules are for. Keep it up.

48 21PurityPaulOR, MaxMetOK, MounjBrad and 45 others
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