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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralGoal weight anxiety — March 2026

Goal weight anxiety — March 2026

dan_philly Sun, Dec 28, 2025 at 5:51 AM 12 replies 970 viewsPage 1 of 3
dan_philly
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Dec 28, 2025 at 5:51 AM#1

Writing this once so I can stop repeating it across threads. It is about mood and mental health, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.

The condition it depends on

For anyone with an eating-disorder history this needs a clinician in the loop rather than a forum. The same drug can be therapeutic in binge-eating disorder and actively harmful in a restrictive disorder.

What I am not sure about

The narrow version of the question is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot. Numbers rather than impressions, if you have them.

— dan_philly · corrections welcome and will be edited into this post with credit
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Dr.ReproEndo
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Dec 28, 2025 at 7:26 AM#2
dan_philly said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

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Dr.SportsMedIN
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Dec 28, 2025 at 9:01 AM#3
dan_philly said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

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jim_asheville
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Dec 28, 2025 at 10:36 AM#4
Dr.SportsMedIN said:
I would be careful about how confidently the flatness reports get attributed.

Before/after narrative for mental health — one year in:

Before (294 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (189 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 94 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

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oliver_london
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Dec 28, 2025 at 7:51 PM#5
Dr.ReproEndo said:
Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming…

Mine went the same way, slower. I had assumed I was the exception until I read this.

Last edited: Dec 28, 2025 at 8:51 PM
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