Retatrutide anticipation thread — what are your questions for Phase 3?

Dr.PathRoch said:

The gap between trial results and real-world results is consistent and it is not fraud.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

maria_elpaso said:

The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

This is exactly what I could not find anywhere else.

Dr.PathRoch said:

The gap between trial results and real-world results is consistent and it is not fraud.

Pushing back on Dr.PathRoch here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

One concrete data point for the thread. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.