One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
One thing that is still open after Dr.LipidDallas’s answer:
Did your prescriber agree with that reading, and if not what was their objection?
BiostatsBrad said:The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…
Coming at BiostatsBrad’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.
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Shop Reference StandardsClosing the loop on my own question.
Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.
Dr.PathRoch said:The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.
Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.