Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago said:

What actually changed my mind was the point about waiting for a trend instead of reading a single measurement, which is embarrassing in hindsight and…

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Happy to go further on any of that.

Dr.EM_Chicago said:

What actually changed my mind was the point about waiting for a trend instead of reading a single measurement, which is embarrassing in hindsight and…

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

Worth separating that from liver and MASH, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Dr.EM_Chicago said:

What actually changed my mind was the point about waiting for a trend instead of reading a single measurement, which is embarrassing in hindsight and…

Saving this. It is the first explanation that did not require me to already understand it. Adding it to my notes with a link back to this thread.

From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

CarlaRPh_TPA said:

It is worth asking what the claim would look like if it were false.

Same experience, arrived at from the opposite direction. Nothing to add that would improve it.