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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 4

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 4 of 9
anna.melb_AU
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Feb 4, 2025 at 9:40 PM#16

Clinical perspective, offered as context rather than as advice. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

48 21DerekSJ_a1c, paige_pharma, emma_london and 45 others
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NurseLeah_Nash
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Feb 5, 2025 at 7:27 AM#17
dave_SLC said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

This answered a question I did not know how to ask.

49 22BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 46 others
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Dr.SurgeonPGH
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Feb 5, 2025 at 5:13 PM#18

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Last edited: Feb 5, 2025 at 8:13 PM
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ZaraB_AL
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Feb 6, 2025 at 2:59 AM#19
Dr.SurgeonPGH said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

This matches mine closely enough to be worth saying so out loud.

Last edited: Feb 6, 2025 at 3:59 AM
1 24TrialTracker_MD
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Admin
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Feb 6, 2025 at 12:45 PM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

23 21PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 20 others
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