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ForumsCompounding & FormulationEndotoxin testing in compounded injectables — LAL vs rFC methods Page 3

Endotoxin testing in compounded injectables — LAL vs rFC methods

LabKate Sat, Jun 6, 2026 at 12:43 AM 17 replies 423 viewsPage 3 of 4
steph_laguna
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Jun 6, 2026 at 6:49 PM#11
Dr.RenalNash said:
Resolution therefore closed the doors unevenly, and the asymmetry follows from the bulks lists.

This answered a question I did not know how to ask. Taking it to my next appointment.

Last edited: Jun 7, 2026 at 12:49 AM
27 0Dr.EndoEP, GraceAZ_72, carl_compliance and 24 others
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SleepDoc_PDX
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Jun 7, 2026 at 12:05 AM#12

Clinical perspective, offered as context rather than as advice.

Compounding pharmacy customer here with experience relevant to compounded supply.

I've ordered from 2 different compounding pharmacies over the past 2 years. The quality variation is real — purity ranged from 94% to 101% of label claim based on independent Janoshik testing.

My current compounder (a 503B facility) has been consistently 98-101% purity across 10 orders. I pay $133/month vs $1,323 for brand. The savings are substantial and the product is equivalent in my experience.

Re: compounded supply — this applies whether you're using brand or compounded. The clinical principles are the same.

28 1hank_denver, carlos_SATX, sophie_paris and 25 others
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FDA_TrackerJim
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Jun 7, 2026 at 5:21 AM#13
Dr.EndoEP said:
Compounding pharmacy licensing verification for compounded supply: before ordering, verify your pharmacy's credentials: State Board of Pharmacy…

Compounded has been just as effective for me. If compounded supply is the concern, the COA from my 503B pharmacy shows 99.1% purity. Verified by Janoshik.

29 2MikeNYC_runner and 26 others
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josh_phd_bmore
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Jun 7, 2026 at 10:38 AM#14
LabKate said:
The shortage clause is the answer to the second question and it is a subtraction rather than an addition.

I have been on both brand and compounded, and in the context of compounded supply, my experience has been equivalent with both. The key is finding a reliable 503B pharmacy with independent testing.

Last edited: Jun 7, 2026 at 12:38 PM
30 3KarenAZ_mom, zoe_NC, Dr.ObesityLA and 27 others
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mike_mod
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Jun 7, 2026 at 3:54 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

Last edited: Jun 7, 2026 at 5:54 PM
31 4PurityPaulOR, MaxMetOK, MounjBrad and 28 others
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