Rybelsus real-world vs clinical trial efficacy — what worked for you?

Dr.DermMIA said:

Relative and absolute effects need reading together.

Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.

EndoResFellow said:

Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

Dr.DermMIA said:

Relative and absolute effects need reading together.

Pushing back on Dr.DermMIA here. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Ask again with the specifics and you will get a better answer than this one.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.