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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPsychological & BehavioralAnyone else feel guilty for using a drug to lose weight?

Anyone else feel guilty for using a drug to lose weight?

SaraMom3 Mon, Apr 27, 2026 at 5:24 AM 20 replies 933 viewsPage 1 of 4
SaraMom3
Member
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Aug 2024
Ohio
Apr 27, 2026 at 5:24 AM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

What I actually want to know is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Not looking for reassurance. Looking for the part I have got wrong.

5 0BethLabQueen, ChrisMacros, KetoKyle and 2 others
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JennaRN
Senior Member
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Mar 2024
Colorado
Online
Apr 27, 2026 at 5:35 AM#2
SaraMom3 said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
4 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 1 other
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fiona_VT
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Dec 2024
Vermont
Apr 27, 2026 at 5:46 AM#3
JennaRN said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

3 23jason_sac26, chris_chi24, tampaLisa73
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tammy_FL
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Nov 2024
Tampa, FL
Apr 27, 2026 at 5:57 AM#4
SaraMom3 said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.

Last edited: Apr 27, 2026 at 11:57 AM
2 22Dr.PainCLE, mike_mealprep
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newstart_MO
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Feb 2026
Springfield, MO
Apr 27, 2026 at 6:52 AM#5

From the other side of the consultation, briefly.

Recovering from an eating disorder and using mental health: this is a complex situation and I want to be transparent about it.

I have a history of binge eating disorder. My psychiatrist, therapist, and prescribing doctor all collaborate on my care. The GLP-1 agonist has actually been therapeutic — it removes the biological urgency of binge impulses without relying on restriction.

This is NOT appropriate for all ED patients. Anorexia, bulimia, and restrictive EDs require different approaches. But for BED specifically, the evidence and my personal experience are positive. Always involve your mental health team.

1 21RunnerRach
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