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ForumsOral GLP-1 AgonistsATTAIN-2: orforglipron in T2DM — 12 month update Page 7

ATTAIN-2: orforglipron in T2DM — 12 month update

RetaRick_CA Sat, Aug 16, 2025 at 1:22 PM 35 replies 1,535 viewsPage 7 of 7
SleepDoc_PDX
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Sep 5, 2025 at 3:48 PM#31
bri_stats said:
Practical: whatever you change, write down the date and the reason.

This is exactly what I could not find anywhere else.

23 23pete_nash, hank_denver, carlos_SATX and 20 others
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Dr.LipidDallas
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Sep 6, 2025 at 6:57 PM#32

From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

22 22wei_SG, cory_ATX, lori_vegas and 19 others
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SteveThurs
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Sep 7, 2025 at 10:06 PM#33
Dr.LipidDallas said:
It is worth asking what the claim would look like if it were false.

Same experience, arrived at from the opposite direction.

21 21SleepFixSam, PurityPaulOR, MaxMetOK and 18 others
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LipidDoc_ATL
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Sep 9, 2025 at 1:14 AM#34
Dr.LipidDallas said:
It is worth asking what the claim would look like if it were false.

Coming at Dr.LipidDallas’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

20 20DebRD_ATL, KristenIndy, MarkLI_maint and 17 others
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anders_CPH
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Sep 10, 2025 at 4:22 AM#35

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Ask again with the specifics and you will get a better answer than this one.

19 19ChrisMacros, KetoKyle, CanadaChris and 16 others
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