Small molecule vs peptide GLP-1 agonists — anyone have experience?

Dr.SurgeonPGH said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

I would rather be corrected than agreed with, if it comes to it.

tammy_FL said:

The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. Adding it to my notes with a link back to this thread.

Dr.SurgeonPGH said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.