Fitness tracker recommendations — 12 month update

andrew_nyc said:

Dr.MetabolicMD said: ...regarding food noise mechanism of action...

Central vs peripheral GLP-1R signaling in food noise: elegant studies using brain-penetrant vs peripherally-restricted GLP-1 agonists show that ~80% of the weight loss effect is centrally mediated[1].

The key brain regions: arcuate nucleus (appetite), area postrema (nausea), NTS (satiety), VTA/NAc (reward). Peripheral effects (gastric emptying, insulin secretion) contribute but are secondary for weight loss.

This has implications for next-gen drugs: optimizing brain penetration and CNS receptor occupancy may be more important than systemic exposure.

RickReta_CO said:

Phantom hunger vs real hunger on food noise: learning to distinguish between the two has been a revelation.

Saving this. It is the first explanation that did not require me to already understand it. Printing the relevant bit and taking it with me.

andrew_nyc said:

Dr.MetabolicMD said: ...regarding food noise mechanism of action...

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here.