Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
Correct me if the detail matters more than I have assumed.
Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.
NurseLeah_Nash said:It is worth asking what the claim would look like if it were false.
This matches mine closely enough to be worth saying so. Steady state is the thing most people miss. The terminal half-life is about a week, so every dose step takes four to five weeks to fully express itself. Judging a step at day ten is judging the ascent, not the plateau, and it is the single commonest reason people escalate before they needed to.
I would rather be corrected than agreed with, if it comes to it.
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View ResultsNurseLeah_Nash said:It is worth asking what the claim would look like if it were false.
Adding the part of the answer the thread has not reached. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.
Correct me if the detail matters more than I have assumed.