A reference post rather than a discussion. Corrections are the point; I would rather this be right than mine. It is about a stall, and it is deliberately narrow — everything I am not confident about is marked as such.
What is actually established
Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.
The condition it depends on
The early-responder data is relevant to expectations: roughly 3% loss by week four at a therapeutic dose predicts a strong result at a year. It does not mean someone below that will not respond, but it changes how long you should wait before changing something.
What I am not sure about
The narrow version of the question is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. If the honest answer is that nobody knows, that is a useful answer and I would rather have it.
— Dr.ObesityMed · corrections welcome and will be edited into this post with credit