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ForumsPublic SquareSELECT trial 4-year follow-up data released — sustained MACE reduction Page 4

SELECT trial 4-year follow-up data released — sustained MACE reduction

Dr.CardioMD Mon, Jun 8, 2026 at 11:48 AM 16 replies 240 viewsPage 4 of 4
CanadaChris
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Jun 8, 2026 at 9:13 PM#16
Dr.LipidDallas said:
Lp(a) and cardiovascular risk: a nuance that matters.

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

39 14Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 36 others
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CarlaRPh_TPA
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Jun 8, 2026 at 9:40 PM#17

Adding the clinical framing, because it changes how the question reads.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off metoprolol entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

38 13ricardo_MIA, BrianDallas92, labquiet_amy and 35 others
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KetoKyle
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Jun 8, 2026 at 10:07 PM#18
CarlaRPh_TPA said:
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off metoprolol entirely!

Adding a me-too, because a thread of one person's experience is not much use. The detail I would add is minor and it is already implied above.

37 12pat_auckland, Dr.GastroMayo, JakeBK_lifts and 34 others
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TomTeleRx
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Jun 8, 2026 at 10:34 PM#19
CarlaRPh_TPA said:
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off metoprolol entirely!

Coming at CarlaRPh_TPA’s question from a different direction. Read four things before the headline number. The population, because trial populations are selected and supported in ways that real cohorts are not. The comparator, because "better than placebo" and "better than the current standard" are different claims and get reported identically. The primary endpoint as pre-registered, because a secondary endpoint promoted after the fact is a hypothesis rather than a finding. And the completion rate, because a large effect in the half of participants who finished is a different result from a large effect in everybody enrolled.

Happy to go further on any of that.

36 11HPLC_Greg, LibrarianMeg, bri_stats and 33 others
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mike_mod
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Jun 8, 2026 at 11:01 PM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Tagging this one for the weekly digest.

14 14PurityPaulOR, MaxMetOK, MounjBrad and 11 others
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