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ForumsOff-TopicRoad trip snack guide — my results so far Page 3

Road trip snack guide — my results so far

wendy_avl Wed, Apr 16, 2025 at 12:11 PM 24 replies 1,894 viewsPage 3 of 5
zoe_NC
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Apr 17, 2025 at 10:56 AM#11
Dr.MetabolicMD said:
Rebound hunger after missed dose of food noise: I missed my injection by 3 days due to a shipping delay and the hunger came ROARING back.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.

8 8Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 5 others
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JenPlateau
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Apr 17, 2025 at 2:33 PM#12

From the other side of the consultation, briefly.

wendy_avl said:
...regarding food noise mechanism of action...

To build on this — the mechanism is more complex than "it makes you less hungry." GLP-1 agonists:

  1. Activate hypothalamic satiety centers (appetite reduction)
  2. Delay gastric emptying (prolonged fullness)
  3. Potentiate glucose-dependent insulin secretion
  4. Suppress glucagon secretion
  5. Modulate reward pathway dopaminergic signaling
  6. Reduce hepatic lipogenesis
  7. Have direct cardiovascular protective effects

It's a multi-target drug with systemic metabolic effects. Understanding the mechanism helps us predict and manage side effects.

7 7TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 4 others
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PeptideChemSF
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Apr 17, 2025 at 6:10 PM#13
Dr.EndoEP said:
"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.

I read this differently from Dr.EndoEP, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

6 6FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 3 others
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Dr.PulmRoch
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Apr 17, 2025 at 9:47 PM#14

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Last edited: Apr 17, 2025 at 10:47 PM
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mike_mod
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Apr 18, 2025 at 1:24 AM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Tagging this one for the weekly digest.

Last edited: Apr 18, 2025 at 3:24 AM
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