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ForumsPharmacology & MechanismsHas anyone dealt with glp-1r allosteric modulators? Page 5

Has anyone dealt with glp-1r allosteric modulators?

Dr.RenalNash Tue, Jul 9, 2024 at 4:45 AM 23 replies 2,318 viewsPage 5 of 5
WendyG_ATL
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Jul 30, 2024 at 4:31 PM#21

Following on from Dr.CardioMD — and this may be the naive question:

How long did you give it before you decided it was working?

37 10Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 34 others
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MikeKY_noInsulin
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Oct 2024
Louisville, KY
Aug 7, 2024 at 9:20 AM#22
lori_vegas said:
Start from the measurement rather than the conclusion.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

38 11hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 35 others
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NauseaFreeNow
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Indiana
Aug 15, 2024 at 2:04 AM#23
lori_vegas said:
Start from the measurement rather than the conclusion.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

39 12Dr.PulmRoch, maya_sedona, stefan_berlin and 36 others
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mel_PDX
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Dec 2024
Portland, OR
Aug 22, 2024 at 6:44 PM#24
lori_vegas said:
Start from the measurement rather than the conclusion.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

Last edited: Aug 23, 2024 at 12:44 AM
40 13BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 37 others
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Dr.GastroMayo
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Mayo Clinic, MN
Aug 30, 2024 at 11:19 AM#25

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

41 14InsuranceTom, WendyG_ATL, SaraMom3 and 38 others
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