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ForumsMetabolic Health & DiabetesPost-prandial glucose control — need advice

Post-prandial glucose control — need advice

Dr.ObesityMed Wed, Apr 16, 2025 at 10:23 AM 29 replies 1,656 viewsPage 1 of 6
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Dr.ObesityMed
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Apr 16, 2025 at 10:23 AM#1

Posting this because the summary going around does not say what the paper says, and the difference matters for how people here are using it.

HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very little. The improvement on this class comes from two directions — direct glucose-dependent insulin secretion and glucagon suppression, plus the indirect effect of weight loss on insulin sensitivity — and the second continues after the first has plateaued.

Where I think it is weakest: the follow-up is short relative to how long people actually take these drugs, so durability is an assumption here rather than a finding.

The question I want answered is why A1C lags the way it does, and what to look at in the meantime if you want to know sooner. I would rather have one careful answer than five confident ones.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
14 9EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 11 others
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InsuranceTom
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Apr 16, 2025 at 12:19 PM#2
Dr.ObesityMed said:
HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very…

Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction than glucose or A1C.

My fasting insulin: 27 → 13 → 5 uIU/mL over 9 months. Target is <7. By the time your fasting glucose is elevated, your insulin has been elevated for YEARS trying to compensate.

Ask your doctor to include fasting insulin in your bloodwork panel. It's cheap (~$20) and incredibly informative.

13 8lucas_SP_BR, lisa_labSD, adam_van and 10 others
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LibrarianMeg
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Apr 16, 2025 at 2:15 PM#3
Dr.ObesityMed said:
HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very…

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)125998983
Insulin (fasting)211396
HOMA-IR5.54.11.71.4
Uric Acid8.86.55.65.1

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

12 7julia.endo, JessicaM_2024, TomFromTexas and 9 others
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CarlaRPh_TPA
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Apr 16, 2025 at 4:11 PM#4
LibrarianMeg said:
Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone: Test Baseline Month 3 Month 6 Month 12…

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 10 months: periods became regular for the first time in years, testosterone levels normalized, acne cleared significantly, and — unexpectedly — I got pregnant naturally after 4 years of trying.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

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robert_kc
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Apr 17, 2025 at 3:36 AM#5
InsuranceTom said:
Fasting insulin is the lab my functional medicine doctor cares about most for glycaemic control: it's a much earlier marker of metabolic dysfunction…

This is my experience too, for whatever a second data point is worth.

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