Structure-activity relationships of GLP-1 analogs — anyone have experience?

MASHdoc_SA said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Dr.NephBHM_UK said:

The mechanism is more central than most summaries suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes.

MASHdoc_SA said:

Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

I read this differently from MASHdoc_SA, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.