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ForumsPharmacology & MechanismsGlucagon receptor signaling — my results so far Page 3

Glucagon receptor signaling — my results so far

Dr.EndoIndy Mon, Nov 11, 2024 at 10:53 PM 15 replies 1,810 viewsPage 3 of 3
Dr.SurgeonPGH
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Nov 15, 2024 at 5:29 AM#11
Dr.CardioMD said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

Last edited: Nov 15, 2024 at 8:29 AM
11 9DoseLogDan, SleepFixSam, PurityPaulOR and 8 others
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wanda_boise
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Nov 18, 2024 at 3:31 AM#12
Dr.SurgeonPGH said:
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were…

Genuinely useful, thank you. I had the facts and not the framework. Sending this to two other people who asked me the same thing last week.

Last edited: Nov 18, 2024 at 8:31 AM
12 10marco_milano, pam_columbus, nick_SD_fit and 9 others
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maria_elpaso
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Nov 21, 2024 at 1:32 AM#13
Dr.CardioMD said:
The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either.

Pushing back on Dr.CardioMD here. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

13 11TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 10 others
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lucas_SP_BR
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Nov 23, 2024 at 11:31 PM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

14 12KarenAZ_mom, zoe_NC, Dr.ObesityLA and 11 others
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Admin
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Nov 26, 2024 at 9:29 PM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Report rather than reply if it drifts again.

15 13PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 12 others
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