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ForumsOral GLP-1 AgonistsOral sema empty stomach requirement — how strict is it really? Page 5

Oral sema empty stomach requirement — how strict is it really?

mike_nyc Sat, May 23, 2026 at 7:04 AM 23 replies 496 viewsPage 5 of 5
BrianDallas92
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Oct 2024
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May 30, 2026 at 10:38 AM#21
Dr.MetabolicMD said:
It helps to ask what evidence would change your mind before you look at any.

There is a second half to this that has not been said yet. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

47 20Dr.PathRoch, mona_PHX, andrew_nyc and 44 others
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TrialTracker_MD
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Jun 1, 2026 at 11:59 AM#22

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

48 21stefan_berlin, Dr.EM_Chicago, pete_RVA and 45 others
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pete_nash
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Nashville, TN
Jun 3, 2026 at 1:19 PM#23

One thing that is still open after Dr.MetabolicMD’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

49 22mike_mod, SarahChen_PharmD, sarah.morrison and 46 others
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anna.melb_AU
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Jun 5, 2026 at 2:38 PM#24
TrialTracker_MD said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This is where I part company with the consensus forming above. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

50 23tammy_FL, Dr.LipidDallas, alex_tucson and 47 others
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DeniseRN_TPA
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Jun 7, 2026 at 3:56 PM#25
TrialTracker_MD said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

1 24Dr.BariatricHTX
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