Adiponectin and leptin changes on GLP-1 therapy — September 2026

Dr.SportsMedIN said:

When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

I read this differently from Dr.SportsMedIN, on substance rather than tone. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

InsuranceTom said:

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Before/after narrative for mental health — one year in:

Before (271 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (176 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 71 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

Dr.PeteFamMed said:

I would be careful about how confidently the flatness reports get attributed.

Body image adjustment with mental health: I've lost 79 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

Following on from AttorneyGrant — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

Reporting back.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.