Oral GLP-1 adherence — will pills improve compliance over injections?

HPLC_Greg said:

Orforglipron is the more interesting oral story because it is not a peptide at all.

I do not accept that the fasting window is a minor inconvenience. Adherence data on daily orals with timing requirements is consistently worse than weekly injections, and a drug you take imperfectly is a lower dose than the one on the box.

Correct me if the detail matters more than I have assumed.

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

JessicaH_TX said:

I do not accept that the fasting window is a minor inconvenience.

Coming at JessicaH_TX’s question from a different direction. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

One thing that is still open after JennaRN’s answer:

Whether the fasting requirement is as strict in practice as the label implies, and what people actually see when they get it wrong?

Closing the loop on my own question.

I moved the tablet to the moment I wake up rather than trying to fit it around breakfast, and the difference in the following weeks was obvious. It was a timing problem, not a dose problem.