hans_munich said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.
stefan_berlin said:The pharmacokinetics explain nearly every practical question asked here.
This answered a question I did not know how to ask. I will report back once I have actually tried it.
hans_munich said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
This is where I part company with the consensus forming above. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.
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View ResultsOne concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.