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ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism Page 3

Orforglipron and hepatic first-pass metabolism

SarahChen_PharmD Thu, Jun 4, 2026 at 7:28 AM 22 replies 441 viewsPage 3 of 5
laura_annarbor
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Jun 4, 2026 at 11:29 AM#11
anders_CPH said:
The manufacturing argument is the underrated one.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

21 19labquiet_amy, emily_PDX, Dr.SleepRoch and 18 others
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Dr.ObesityLA
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Jun 4, 2026 at 2:57 PM#12

Adding the clinical framing, because it changes how the question reads. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Jun 4, 2026 at 3:57 PM
22 20KarenAZ_mom, zoe_NC, Dr.ObesityLA and 19 others
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mike_nyc
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Jun 4, 2026 at 6:26 PM#13
Dr.SportsMedIN said:
The liver data is among the strongest non-weight findings in the class.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

23 21Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 20 others
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DanielChem_CHI
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Jun 4, 2026 at 9:54 PM#14

Adding the numbers, since they settle part of this. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

24 22ben_calgary, patPC_UT, Dr.DermMIA and 21 others
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Admin
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Jun 5, 2026 at 1:23 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: Jun 5, 2026 at 5:23 AM
25 23PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 22 others
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