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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesSUSTAIN-6 to SELECT — what worked for you? Page 8

SUSTAIN-6 to SELECT — what worked for you?

fiona_VT Sat, Aug 16, 2025 at 4:04 PM 38 replies 1,492 viewsPage 8 of 8
Dr.PeteFamMed
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Feb 25, 2026 at 8:12 AM#36

Following on from sophie_paris — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

10 8hyun_seoul, jim_asheville, matt_MKE and 7 others
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MarkLI_maint
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Jun 2024
Long Island, NY
Mar 8, 2026 at 2:38 AM#37
lucas_SP_BR said:
I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.
lucas_SP_BR said:
...we're creating a generation dependent on cardiovascular risk...

I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?

Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.

If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.

11 9TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 8 others
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tampaLisa73
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Tampa, FL
Mar 18, 2026 at 8:58 PM#38
lucas_SP_BR said:
I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.

Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks. Root cause was a combination of reduced caloric intake and mild dehydration.

Fix: minimum 80-100oz water daily, don't skip meals even if you're not hungry (eat small protein-rich snacks), and stand up slowly from sitting/lying positions. Also check your blood pressure — GLP-1-induced weight loss can make BP meds too strong, requiring dose reduction.

12 10sarah_nash92, FitDadDave, RunnerRach and 9 others
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tony_orlando
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Nov 2024
Orlando, FL
Mar 29, 2026 at 3:12 PM#39
lucas_SP_BR said:
I'm 58 years old and want to share my perspective on cardiovascular risk as an older member of this community.

Genuinely useful, thank you. I had the facts and not the framework.

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Dr.ReproEndo
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Apr 9, 2026 at 9:20 AM#40

Adding the clinical framing, because it changes how the question reads.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off amlodipine entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

Last edited: Apr 9, 2026 at 10:20 AM
35 8carl_compliance, DanielChem_CHI, marco_milano and 32 others
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