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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — need advice Page 3

Incretin effect in healthy vs T2DM — need advice

alex_tucson Wed, Mar 26, 2025 at 10:30 AM 13 replies 1,530 viewsPage 3 of 3
Dr.SurgeonPGH
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Mar 27, 2025 at 4:26 AM#11
sean_dublin said:
Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include: Biomarker Association…

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

Correct me if the detail matters more than I have assumed.

11 9DoseLogDan, SleepFixSam, PurityPaulOR and 8 others
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maya_sedona
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Mar 27, 2025 at 2:38 PM#12
CarlaRPh_TPA said:
Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking: HOMA-IR = (fasting…

That reframing is the part I needed. Taking it to my next appointment.

12 10NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 9 others
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Dr.GastroMayo
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Mar 28, 2025 at 12:50 AM#13
sean_dublin said:
Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include: Biomarker Association…

I read this differently from sean_dublin, on substance rather than tone. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

Correct me if the detail matters more than I have assumed.

13 11COA_Karl, MikeFit_NJ, InsuranceTom and 10 others
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DanielChem_CHI
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Mar 28, 2025 at 11:02 AM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Ask again with the specifics and you will get a better answer than this one.

14 12ben_calgary, patPC_UT, Dr.DermMIA and 11 others
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Admin
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Mar 28, 2025 at 9:14 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.

Last edited: Mar 29, 2025 at 1:14 AM
15 13PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 12 others
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