🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesIs it possible to reverse type 2 or am I dreaming — 12 month update Page 2

Is it possible to reverse type 2 or am I dreaming — 12 month update

tane_welly Tue, Sep 2, 2025 at 2:37 PM 7 replies 1,221 viewsPage 2 of 2
dan_philly
Member
456
2,123
Jul 2024
Philadelphia, PA
Sep 3, 2025 at 12:37 AM#6
tane_welly said:
HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very…

My labs after 9 months on glycaemic control: A1C 5.0%, fasting glucose 85 mg/dL, fasting insulin 4 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 6.5% and fasting glucose was 110 mg/dL. The improvement has been dramatic and consistent.

35 5DadBodDave, AmyNC_wife, SkepticalSean and 32 others
Reply Quote Save Share Report
emily_PDX
Member
245
1,123
Nov 2024
Portland, OR
Sep 3, 2025 at 4:35 AM#7

One thing that is still open after Dr.DermMIA’s answer:

Was that from a primary source or from a summary of one?

34 4PharmD_Rodriguez, julia.endo, JessicaM_2024 and 31 others
Reply Quote Save Share Report
NurseKim_ATL
Senior Member
1,678
7,234
Feb 2024
Atlanta, GA
Sep 3, 2025 at 8:33 AM#8
dan_philly said:
My labs after 9 months on glycaemic control: A1C 5.0%, fasting glucose 85 mg/dL, fasting insulin 4 uIU/mL.

Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking:

HOMA-IR = (fasting insulin × fasting glucose) ÷ 405

My numbers: Baseline HOMA-IR = 5.4 (insulin resistant) → Current = 1.4 (insulin sensitive)

Anything above 2.0 indicates insulin resistance. The goal is below 1.5. GLP-1 agonists address the root metabolic dysfunction, not just the symptoms. This is why they work so much better than calorie restriction alone.

33 3ingrid_STO, pete_nash, hank_denver and 30 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
tane_welly
Member
234
1,123
Sep 2024
Wellington, NZ
Sep 3, 2025 at 12:31 PM#9
dan_philly said:
My labs after 9 months on glycaemic control: A1C 5.0%, fasting glucose 85 mg/dL, fasting insulin 4 uIU/mL.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1141049082
Insulin (fasting)2012105
HOMA-IR4.54.01.81.3
Uric Acid8.76.45.75.0

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 4.5 to near 1.0 is a metabolic transformation.

32 2marco_milano, pam_columbus, nick_SD_fit and 29 others
Reply Quote Save Share Report
SleepDoc_PDX
Member
289
1,234
Sep 2024
Portland, OR
Sep 4, 2025 at 7:32 AM#10
NurseKim_ATL said:
Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking: HOMA-IR = (fasting…

Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 36% to 22%. Target is <36%, with <30% being ideal.

Why this matters more than average glucose: large glucose swings cause oxidative stress, endothelial damage, and promote advanced glycation end-products (AGEs). A flat glucose line at 95 mg/dL is metabolically healthier than oscillating between 60 and 160, even if the average is the same.

12 10mel_PDX, Dr.AddMedPHL, newstart_MO and 9 others
Reply Quote Save Share Report

Similar Threads

SUSTAIN-6 to SELECT — the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance — HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria — how GLP-1 addresses all 55 replies
A1C target achievement rates — sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register