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ForumsPharmacology & MechanismscAMP signaling cascade from GLP-1R activation — 12 month update Page 4

cAMP signaling cascade from GLP-1R activation — 12 month update

FitDadDave Wed, Jun 4, 2025 at 2:41 PM 25 replies 1,558 viewsPage 4 of 5
carl_compliance
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Jun 20, 2025 at 7:39 AM#16

From the other side of the consultation, briefly. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

That is the short version; the long version is somebody else's post.

Last edited: Jun 20, 2025 at 10:39 AM
6 4labquiet_amy, emily_PDX, Dr.SleepRoch and 3 others
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quinn_sf
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Jun 22, 2025 at 12:05 AM#17

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Jun 22, 2025 at 6:05 AM
7 5Dr.PathRoch, mona_PHX, andrew_nyc and 4 others
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fiona_glasgow
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Jun 23, 2025 at 4:30 PM#18

A narrower follow-up, since the general answer is now clear:

What would you measure differently if you were starting again?

Last edited: Jun 23, 2025 at 9:30 PM
8 6KevinCompounds, TirzTom, TrialTracker_MD and 5 others
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MounjBrad
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Jun 25, 2025 at 8:54 AM#19
quinn_sf said:
Say what you would expect to see if you were wrong, before you look.

Pushing back on quinn_sf here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

9 7pam_columbus, nick_SD_fit, ben_calgary and 6 others
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mike_mod
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Jun 27, 2025 at 1:18 AM#20

Moderator note: the sourcing question belongs in the vendor section and has been split out.

31 4PurityPaulOR, MaxMetOK, MounjBrad and 28 others
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