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ForumsPharmacology & MechanismsGlucagon receptor signaling — anyone have experience? Page 6

Glucagon receptor signaling — anyone have experience?

AmyNC_wife Fri, Jul 11, 2025 at 11:23 PM 50 replies 2,366 viewsPage 6 of 10
LipidDoc_ATL
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Sep 25, 2025 at 10:35 PM#26
Dr.NateNeph said:
It helps to say which part of this you are uncertain about.

This is my experience too, for whatever a second data point is worth.

Last edited: Sep 26, 2025 at 3:35 AM
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raj_cambridge
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Oct 5, 2025 at 3:35 PM#27
Dr.NateNeph said:
It helps to say which part of this you are uncertain about.

Coming at Dr.NateNeph’s question from a different direction. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

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hank_denver
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Oct 15, 2025 at 8:29 AM#28

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

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robert_kc
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Oct 25, 2025 at 1:18 AM#29

Following on from Dr.NateNeph — and this may be the naive question:

How would you tell the difference between that and the alternative explanation?

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AmyNC_wife
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Nov 3, 2025 at 6:01 PM#30

Closing the loop on my own question.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

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