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ForumsMetabolic Health & DiabetesHOMA-IR tracking on GLP-1 — looking for input Page 5

HOMA-IR tracking on GLP-1 — looking for input

FDA_TrackerJim Tue, Nov 18, 2025 at 8:10 PM 41 replies 1,975 viewsPage 5 of 9
NurseLeah_Nash
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Dec 6, 2025 at 11:18 AM#21

Following on from Dr.LipidDallas — and this may be the naive question:

How long did you give it before you decided it was working?

Last edited: Dec 6, 2025 at 12:18 PM
43 16RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 40 others
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LibrarianMeg
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Dec 13, 2025 at 1:38 PM#22
robert_kc said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

44 17PharmD_Rodriguez, julia.endo, JessicaM_2024 and 41 others
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NurseKim_ATL
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Dec 20, 2025 at 3:53 PM#23
robert_kc said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Ask again with the specifics and you will get a better answer than this one.

45 18ingrid_STO, pete_nash, hank_denver and 42 others
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carlos_SATX
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Dec 27, 2025 at 6:04 PM#24
robert_kc said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Thank you for spelling out the reasoning rather than just the conclusion.

46 19LindaRN_retired, tommy_boulder, hyun_seoul and 43 others
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SleepDoc_PDX
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Jan 3, 2026 at 8:12 PM#25

Adding the clinical framing, because it changes how the question reads. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

That is the short version; the long version is somebody else's post.

47 20mel_PDX, Dr.AddMedPHL, newstart_MO and 44 others
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