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ForumsMetabolic Health & DiabetesContinuous glucose monitor patterns on GLP-1 — anyone have experience? Page 2

Continuous glucose monitor patterns on GLP-1 — anyone have experience?

robert_kc Tue, Dec 2, 2025 at 7:03 PM 12 replies 1,048 viewsPage 2 of 3
LibrarianMeg
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Dec 2, 2025 at 9:13 PM#6
KevinCompounds said:
Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking: HOMA-IR = (fasting…

PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

After 7 months: periods became regular for the first time in years, testosterone levels normalized, acne cleared significantly, and — unexpectedly — I got pregnant naturally after 4 years of trying.

GLP-1 agonists address the insulin resistance at the root of PCOS. For PCOS patients, this isn't "just" a weight loss drug — it's treating our underlying metabolic dysfunction.

46 16Dr.NateNeph, PharmD_Rodriguez, julia.endo and 43 others
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Dr.NateNeph
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Dec 2, 2025 at 10:03 PM#7
robert_kc said:
Fasting glucose improved within weeks and my HbA1c barely moved for three months, which I now understand and did not at the time.

Patient selection optimization for glycaemic control: emerging predictive biomarkers for GLP-1 agonist response include:

BiomarkerAssociationEvidence Level
Baseline BMIHigher BMI → greater absolute weight lossStrong
Fasting insulinHigher insulin → better responseModerate
GLP1R gene variantsrs6923761 → variable responsePreliminary
Baseline hsCRPHigher CRP → greater CV benefitModerate
Early weight loss (4 wk)≥3% at 4 wks → strong predictor of ≥10% at 68 wksStrong

The 4-week early responder criterion is the most clinically actionable: if you haven't lost ≥3% by week 4 at a therapeutic dose, discuss optimization strategies with your provider.

45 15NauseaFreeNow, SteveThurs, B12Beth and 42 others
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Dr.SleepRoch
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Dec 2, 2025 at 10:53 PM#8
LibrarianMeg said:
PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

My labs after 6 months on glycaemic control: A1C 5.9%, fasting glucose 84 mg/dL, fasting insulin 7 uIU/mL. My endo says these are "textbook perfect."

For context, my baseline A1C was 8.3% and fasting glucose was 119 mg/dL. The improvement has been dramatic and consistent.

44 14Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 41 others
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mike_mealprep
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Dec 2, 2025 at 11:43 PM#9

A narrower follow-up, since the general answer is now clear:

Was that from a primary source or from a summary of one?

43 13mel_PDX, Dr.AddMedPHL, newstart_MO and 40 others
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robert_kc
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Dec 3, 2025 at 3:45 AM#10
Dr.SleepRoch said:
My labs after 6 months on glycaemic control: A1C 5.9%, fasting glucose 84 mg/dL, fasting insulin 7 uIU/mL.

Complete metabolic panel trending on glycaemic control — sharing because comprehensive data helps everyone:

TestBaselineMonth 3Month 6Month 12
Glucose (fasting)1211079385
Insulin (fasting)271595
HOMA-IR5.53.72.11.5
Uric Acid8.47.16.05.2

The insulin resistance improvement (HOMA-IR) is what my endo focuses on most. Going from 5.5 to near 1.0 is a metabolic transformation.

21 19PharmHunterJen, TomTeleRx, DoseLogDan and 18 others
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