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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice Page 6

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice

GenomicsKate Sat, Jan 3, 2026 at 11:59 AM 29 replies 1,587 viewsPage 6 of 6
hank_denver
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Feb 9, 2026 at 9:21 AM#26
PeptideChemSF said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

25 23ingrid_STO, pete_nash, hank_denver and 22 others
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Dr.SportsMedIN
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Feb 13, 2026 at 10:20 PM#27
PeptideChemSF said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This is exactly what I could not find anywhere else.

Last edited: Feb 14, 2026 at 3:20 AM
26 24lisa_labSD, adam_van, Dr.SurgeonPGH and 23 others
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KevinCompounds
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Feb 18, 2026 at 11:17 AM#28

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Feb 18, 2026 at 1:17 PM
27 0MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 24 others
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JakeBK_lifts
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Feb 23, 2026 at 12:11 AM#29
KevinCompounds said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Mine went the same way, slower. I had assumed I was the exception until I read this.

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GenomicsKate
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Feb 27, 2026 at 1:02 PM#30

OP back with an update, since a thread like this is useless without one.

Reporting back for the archive rather than for the thread: I did the narrow version of what was suggested, gave it the full interval, and it settled. Posting it because threads without a follow-up are half a thread.

50 23claudia_zurich, nancy_portland, rick_sfbay and 47 others
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