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ForumsPharmacology & MechanismsHas anyone dealt with receptor internalization and recycling? Page 6

Has anyone dealt with receptor internalization and recycling?

steph_laguna Tue, Nov 11, 2025 at 8:29 AM 28 replies 1,190 viewsPage 6 of 6
TrialNerd_Beth
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Nov 16, 2025 at 3:44 PM#26

From the other side of the consultation, briefly. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

Last edited: Nov 16, 2025 at 7:44 PM
25 23RickReta_CO, PharmHunterJen, TomTeleRx and 22 others
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DataDave
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Nov 16, 2025 at 11:13 PM#27
TrialNerd_Beth said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Can confirm. Same sequence, different timescale.

26 24mike_nyc, VendorMark, COA_Karl and 23 others
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FDA_TrackerJim
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Nov 17, 2025 at 6:42 AM#28
TrialNerd_Beth said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Adding the part of the answer the thread has not reached. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Correct me if the detail matters more than I have assumed.

Last edited: Nov 17, 2025 at 9:42 AM
27 0MikeNYC_runner and 24 others
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BethLabQueen
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Nov 17, 2025 at 2:11 PM#29

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

28 1cory_ATX, lori_vegas, Dr.PulmRoch and 25 others
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steph_laguna
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Nov 17, 2025 at 9:40 PM#30

OP back with an update, since a thread like this is useless without one.

Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

Last edited: Nov 18, 2025 at 3:40 AM
50 23marco_milano, pam_columbus, nick_SD_fit and 47 others
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