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ForumsPharmacology & MechanismsPeptide degradation pathways — anyone have experience? Page 3

Peptide degradation pathways — anyone have experience?

lori_vegas Tue, Nov 18, 2025 at 12:24 PM 26 replies 1,236 viewsPage 3 of 6
COA_Karl
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Nov 20, 2025 at 4:49 AM#11
Dr.NateNeph said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

5 3matt_MKE, Dr.ReproEndo, lucas_SP_BR and 2 others
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Dr.EndoEP
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Nov 21, 2025 at 7:16 AM#12
Dr.MetabolicMD said:
The mechanism is more central than most summaries suggest.

Saving this. It is the first explanation that did not require me to already understand it.

6 4james_edin, FranDenver, Dr.BariatricHTX and 3 others
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ingrid_STO
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Nov 22, 2025 at 9:42 AM#13
Dr.NateNeph said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Pushing back on Dr.NateNeph here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

7 5MikeFit_NJ, InsuranceTom, WendyG_ATL and 4 others
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PharmacoVig_BOS
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Nov 23, 2025 at 12:08 PM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Nov 23, 2025 at 3:08 PM
8 6kate.chem, DataDave, Dr.GutHealth and 5 others
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Admin
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Nov 24, 2025 at 2:33 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

9 7PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 6 others
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