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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — what worked for you? Page 3

Biased agonism at GLP-1R — what worked for you?

KarenAZ_mom Thu, Jan 22, 2026 at 7:21 AM 13 replies 1,056 viewsPage 3 of 3
Dr.AddMedPHL
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Jan 27, 2026 at 2:53 PM#11
hans_munich said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

22 20FitDadDave, RunnerRach, TrialNerd_Beth and 19 others
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maya_sedona
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Jan 28, 2026 at 4:16 AM#12
LibrarianMeg said:
The mechanism is more central than most summaries suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. I will report back once I have actually tried it.

23 21NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 20 others
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JennaRN
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Jan 28, 2026 at 5:39 PM#13
hans_munich said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

This is where I part company with the consensus forming above. Pushing back on the consensus forming here. Consistency is not the same as correctness, and a board that agrees with itself quickly is usually agreeing with the first person who sounded certain.

Last edited: Jan 28, 2026 at 6:39 PM
24 22BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 21 others
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bri_stats
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Jan 29, 2026 at 7:02 AM#14

One concrete data point for the thread. Practical: whatever you change, write down the date and the reason. In three months the reason is what you will have forgotten, and the reason is what makes the record worth having.

Last edited: Jan 29, 2026 at 11:02 AM
25 23JessicaM_2024, TomFromTexas, mike.trainer_LA and 22 others
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mike_mod
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Jan 29, 2026 at 8:26 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

26 24PurityPaulOR, MaxMetOK, MounjBrad and 23 others
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