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ForumsDosing & ProtocolsInjection bruise the size of a quarter - normal?? — 12 month update Page 2

Injection bruise the size of a quarter - normal?? — 12 month update

A1cHero_PHX Sat, Mar 15, 2025 at 7:09 PM 49 replies 2,151 viewsPage 2 of 10
NeuroNate
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Mar 16, 2025 at 12:15 AM#6
amsterdam_pete said:
The trials generally allowed a step to be held or reduced and then retried, and people who did that mostly arrived at the same place a few weeks…

I disagree that the ladder is purely tolerability. The maintenance and regain data cluster at the top doses, so a ladder abandoned halfway leaves you outside the evidence base for the part that matters most — keeping it off.

42 12jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 39 others
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lucas_SP_BR
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Mar 16, 2025 at 2:15 AM#7
A1cHero_PHX said:
I titrated faster than the label because I felt fine, hit a wall at the third step, and had to come back down — which I now think was the predictable…

Dose escalation anxiety for titration: I was terrified to move from 0.5mg to 1.0mg based on horror stories in this forum. But my actual experience? Slightly more appetite suppression, zero additional side effects.

Remember that the people posting about terrible side effects are a biased sample. Most people titrate up without drama — they just don't post about it because it's uneventful.

41 11Dr.ObesityLA, NurseKim_ATL, paul_denver and 38 others
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JenPlateau
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Mar 16, 2025 at 4:15 AM#8
NeuroNate said:
I disagree that the ladder is purely tolerability.

Adding the part of the answer the thread has not reached. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Mar 16, 2025 at 10:15 AM
40 10RunnerRach, TrialNerd_Beth, HPLC_Greg and 37 others
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mel_PDX
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Mar 16, 2025 at 6:15 AM#9

Following on from maya_sedona — and this may be the naive question:

Why the interval is four weeks rather than two, and whether a slower ladder gets to the same place?

39 9BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 36 others
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A1cHero_PHX
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Mar 16, 2025 at 3:53 PM#10

OP back with an update, since a thread like this is useless without one.

I held the step an extra three weeks instead of stepping back down, and it settled. Same dose, same everything, just more time — which is exactly what was suggested upthread.

Last edited: Mar 16, 2025 at 8:53 PM
45 18jason_sac26, chris_chi24, tampaLisa73 and 42 others
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