⚠ Fake COAs — looking for input

Dr.KarenChen said:

My vendor review relevant to certificates of analysis: ordered 4 times from my current compounder.

Reconstituted peptide stability data for certificates of analysis: I had Janoshik test my reconstituted vial at day 1, day 14, and day 28 stored in the refrigerator.

Day 1: 99.6% purity
Day 14: 98.0% purity
Day 28: 97.0% purity

Minimal degradation over 28 days when properly refrigerated. This confirms the standard 28-day beyond-use date is appropriate. Beyond 28 days, I'd reconstitute a fresh vial to be safe.

pam_columbus said:

One addition: an unstated method makes a report close to uninterpretable.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Dr.KarenChen said:

My vendor review relevant to certificates of analysis: ordered 4 times from my current compounder.

I tested my certificates of analysis batch through Janoshik — 99.5% purity. That's within acceptable range for compounded peptides. Turnaround was 12 business days.

The test costs ~$137 but gives you actual HPLC chromatography data plus mass spec confirmation. For the peace of mind alone, it's worth every penny. I test every new batch from a new vendor.

mark_tokyo said:

Two reports on the same product from two laboratories, four percentage points apart, and no method stated on either.

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis:

• No HPLC data: If there's no chromatography graph, it's not a real COA
• Exact 100% purity: Suspicious — real testing always shows slight variation
• No batch number: Can't trace back to specific production
• No endotoxin testing: For injectables, this is essential
• Template looks like it was made in Word: Professional labs have standardized formats

I have seen fake COAs that are literally photoshopped. Always verify independently if possible.

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.