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ForumsPharmacology & MechanismscAMP signaling cascade from GLP-1R activation — what worked for you? Page 3

cAMP signaling cascade from GLP-1R activation — what worked for you?

sophie_paris Fri, Apr 10, 2026 at 2:09 AM 13 replies 633 viewsPage 3 of 3
Dr.PainCLE
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Apr 13, 2026 at 2:01 PM#11
Dr.LeslieOBGYN said:
I want to add the drug interaction perspective on the pharmacology.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Last edited: Apr 13, 2026 at 5:01 PM
9 9Dr.PathRoch, mona_PHX, andrew_nyc and 6 others
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SallyK_inj
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Apr 16, 2026 at 1:30 AM#12
Dr.CardioMD said:
The pharmacokinetics explain nearly every practical question asked here.

That reframing is the part I needed. Printing the relevant bit and taking it with me.

8 8bbq_ray_KC, oliver_london, tane_welly and 5 others
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mike_mealprep
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Apr 18, 2026 at 12:58 PM#13
Dr.LeslieOBGYN said:
I want to add the drug interaction perspective on the pharmacology.

Pushing back on Dr.LeslieOBGYN here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

7 7Dr.AddMedPHL, newstart_MO, mia_MS2 and 4 others
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dan_philly
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Apr 21, 2026 at 12:24 AM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

6 6Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 3 others
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Admin
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Apr 23, 2026 at 11:49 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.

Last edited: Apr 23, 2026 at 3:49 PM
5 5PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 2 others
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