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ForumsDosing & ProtocolsWhen to hold at a dose vs continue titrating — looking for input Page 3

When to hold at a dose vs continue titrating — looking for input

rick_sfbay Tue, Sep 2, 2025 at 4:03 AM 13 replies 1,233 viewsPage 3 of 3
PedsEndoPhilly
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Sep 5, 2025 at 5:20 AM#11
Dr.SurgeonPGH said:
A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component…

Thank you — that is the clearest version of this I have read, and I have read a lot of them.

50 0sarah_TO, wendy_avl, jason_paloalto and 47 others
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Dr.EM_Chicago
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Sep 8, 2025 at 1:34 AM#12

Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

49 24matt_MKE, Dr.ReproEndo, lucas_SP_BR and 46 others
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mike.trainer_LA
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Sep 10, 2025 at 9:46 PM#13
chris_chi24 said:
Dose escalation anxiety for titration: I was terrified to move from 0.5mg to 1.0mg based on horror stories in this forum.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

48 23mia_MS2, LeilaHI, marcus_mpls and 45 others
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jason_paloalto
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Sep 13, 2025 at 5:57 PM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Ask again with the specifics and you will get a better answer than this one.

47 22andrew_nyc, Dr.EndoEP, GraceAZ_72 and 44 others
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mike_mod
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Sep 16, 2025 at 2:07 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.

46 21PurityPaulOR, MaxMetOK, MounjBrad and 43 others
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