🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsStructure-function of tirzepatide — unimolecular dual agonist design Page 3

Structure-function of tirzepatide — unimolecular dual agonist design

PeptideChemSF Thu, May 21, 2026 at 12:31 AM 14 replies 437 viewsPage 3 of 3
mona_PHX
Member
189
890
Dec 2024
Phoenix, AZ
May 26, 2026 at 12:38 PM#11
JenPlateau said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

30 5RetaRick_CA, JenPlateau, SallyK_inj and 27 others
Reply Quote Save Share Report
sophie_paris
Member
212
890
Nov 2024
Paris, FR
May 26, 2026 at 8:24 PM#12

From the other side of the consultation, briefly. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

29 4CryptoCarl, MariaRD, AussieAnna and 26 others
Reply Quote Save Share Report
TrialTracker_MD
Senior Member
2,345
15,678
Jan 2024
Maryland
May 27, 2026 at 4:10 AM#13
Dr.ObesityLA said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I read this differently from Dr.ObesityLA, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

28 3maya_sedona, stefan_berlin, Dr.EM_Chicago and 25 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
Dr.PeteFamMed
Senior Member
2,012
9,234
Jan 2024
Minneapolis, MN
May 27, 2026 at 11:56 AM#14

The figures, for anyone assembling their own picture. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: May 27, 2026 at 12:56 PM
27 2Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 24 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
May 27, 2026 at 7:42 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

26 1PurityPaulOR, MaxMetOK, MounjBrad and 23 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register