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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — why GLP-1 response is blunted in diabetes Page 3

Incretin effect in healthy vs T2DM — why GLP-1 response is blunted in diabetes

Dr.MetabolicMD Mon, May 25, 2026 at 12:30 AM 13 replies 471 viewsPage 3 of 3
KetoKyle
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May 29, 2026 at 9:22 PM#11
carl_compliance said:
My labs after 12 months on glycaemic control: A1C 5.7%, fasting glucose 82 mg/dL, fasting insulin 5 uIU/mL.

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

Last edited: May 29, 2026 at 10:22 PM
36 11laura_annarbor, JenMemphis, pat_auckland and 33 others
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PedsEndoPhilly
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Jun 1, 2026 at 2:48 AM#12

Clinical perspective, offered as context rather than as advice. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

35 10wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 32 others
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RetaRick_CA
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Jun 3, 2026 at 8:16 AM#13
Dr.EndoIndy said:
PCOS success story with glycaemic control: as someone with polycystic ovary syndrome, this medication has been transformative beyond weight loss.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

34 9DadBodDave, AmyNC_wife, SkepticalSean and 31 others
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raj_cambridge
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Cambridge, MA
Jun 5, 2026 at 1:44 PM#14

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

33 8PharmHunterJen, TomTeleRx, DoseLogDan and 30 others
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mike_mod
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Jun 7, 2026 at 7:14 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

32 7PurityPaulOR, MaxMetOK, MounjBrad and 29 others
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