Tachyphylaxis vs tolerance — pharmacological distinction on GLP-1

paige_pharma said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.

Dr.PeteFamMed said:

Keep the original post as written when you update it, and add the correction underneath.

There is a second half to this that has not been said yet. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

One concrete data point for the thread. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Following on from Dr.PeteFamMed — and this may be the naive question:

How long did you give it before you decided it was working?

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.