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ForumsPharmacology & MechanismsGlucagon receptor signaling — hepatic glycogenolysis and lipolysis Page 2

Glucagon receptor signaling — hepatic glycogenolysis and lipolysis

Dr.MetabolicMD Sun, Jun 7, 2026 at 2:56 AM 16 replies 226 viewsPage 2 of 4
raj_cambridge
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Jun 7, 2026 at 8:08 AM#6

Adding the numbers, since they settle part of this. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.

That is the short version; the long version is somebody else's post.

Last edited: Jun 7, 2026 at 9:08 AM
12 7SleepFixSam, PurityPaulOR, MaxMetOK and 9 others
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TinaHashiRN
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Jun 7, 2026 at 10:11 AM#7

One thing that is still open after Dr.SleepRoch’s answer:

Whether normalised enzymes tell you anything about fibrosis, and what the right follow-up measurement is?

11 6mike_mod, SarahChen_PharmD, sarah.morrison and 8 others
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Dr.SurgeonPGH
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Jun 7, 2026 at 12:15 PM#8
raj_cambridge said:
With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most…

Coming at raj_cambridge’s question from a different direction. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Last edited: Jun 7, 2026 at 3:15 PM
10 5PharmHunterJen, TomTeleRx, DoseLogDan and 7 others
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Dr.MetabolicMD
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Jun 7, 2026 at 2:19 PM#9

OP back with an update, since a thread like this is useless without one.

Closing the loop. The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

9 4Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 6 others
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paige_pharma
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Jun 8, 2026 at 12:14 AM#10
Dr.SurgeonPGH said:
It helps to say which part of this you are uncertain about.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Last edited: Jun 8, 2026 at 1:14 AM
21 19lucas_SP_BR, lisa_labSD, adam_van and 18 others
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