Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.
Clinical perspective, offered as context rather than as advice. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.
PharmacoVig_BOS said:It helps to say which part of this you are uncertain about.
This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.
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Shop Reference StandardsPharmacoVig_BOS said:It helps to say which part of this you are uncertain about.
Coming at PharmacoVig_BOS’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.
Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.