Sema prices are all over the place — 6 month update

Adding the clinical framing, because it changes how the question reads. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

Ask again with the specifics and you will get a better answer than this one.

Following on from CarlaRPh_TPA — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

TrialTracker_MD said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

I read this differently from TrialTracker_MD, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

TrialTracker_MD said:

Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.