BiostatsBrad said:Worth knowing that the injection site changes very little.
I disagree that the ladder is purely tolerability. The maintenance and regain data cluster at the top doses, so a ladder abandoned halfway leaves you outside the evidence base for the part that matters most — keeping it off.
BiostatsBrad said:Worth knowing that the injection site changes very little.
Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.
BiostatsBrad said:Worth knowing that the injection site changes very little.
That reframing is the part I needed. Printing the relevant bit and taking it with me.
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Shop Reference StandardsClinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.
Closing the loop on my own question.
Update. I did go to 2.4mg in the end, and the honest report is that it bought me less than the step before it and cost me two bad weeks. Worth knowing rather than worth repeating.