Omega-3 supplementation — anyone have experience?

Dr.GutHealth said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Agreeing with Dr.GutHealth, and the qualification matters more than the agreement. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

Dr.GutHealth said:

On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

Taking the question as asked, rather than the general version of it. Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

Dr.NateNeph said:

The RDA is the wrong reference and it is worth understanding why.

This matches mine closely enough to be worth saying so out loud. Nothing to add that would improve it.