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ForumsNutrition & SupplementationPlant-based protein sources for vegan GLP-1 users — anyone have experience?

Plant-based protein sources for vegan GLP-1 users — anyone have experience?

DataDave Sat, Apr 5, 2025 at 2:33 PM 15 replies 1,728 viewsPage 1 of 3
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DataDave
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Apr 5, 2025 at 2:33 PM#1

This is the version of the explanation I wish somebody had given me, written down before I forget what confused me. It is about protein intake, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

Distribution matters less than total but it is not nothing. Roughly 25 to 40g per sitting with enough leucine to trigger synthesis, three or four times a day, is more effective than the same total in one enormous evening meal — and on a suppressed appetite the enormous evening meal is the one you will not finish anyway.

The condition it depends on

Anyone with reduced kidney function needs that target set by a clinician rather than a forum. High protein is safe in normal kidneys and is not automatically safe in impaired ones.

The practical version

The arithmetic that makes it tractable: reference weight in kg times 1.6 gives the target; divide by four for a per-sitting figure; then find four foods that hit that figure in a volume you can actually finish. Most people need two of the four to be liquid or semi-liquid early on.

What I am not sure about

What I am after is whether the RDA is the wrong reference entirely during rapid weight loss, and what the actual target should be. Practical detail welcome, however dull — the duller the better.

— DataDave · corrections welcome and will be edited into this post with credit
28 23VendorMark, COA_Karl, MikeFit_NJ and 25 others
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TrialNerd_Beth
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Apr 5, 2025 at 3:37 PM#2
DataDave said:
Distribution matters less than total but it is not nothing.

DataDave has the substance of this right. The condition it depends on is worth stating. On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie. Isolate powders, Greek yoghurt and cottage cheese, egg whites, lean fish, and tinned tuna all deliver a lot of protein in a small physical volume. Front-load it: appetite is usually least suppressed in the first hours after waking and worst on the day or two after dosing, so get the majority in early in the day and early in the week.

Correct me if the detail matters more than I have assumed.

27 22PharmHunterJen, TomTeleRx, DoseLogDan and 24 others
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Dr.ObesityMed
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Apr 5, 2025 at 4:41 PM#3
DataDave said:
Distribution matters less than total but it is not nothing.

I will push back on the powder-first advice. It works and it also trains people out of eating food, and when the drug stops the habits are what remain. Getting protein from meals is slower and holds up better afterwards.

26 21SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 23 others
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NurseKim_ATL
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Apr 5, 2025 at 5:45 PM#4

This one has a reasonably settled answer, so here it is. The RDA is the wrong reference and it is worth understanding why. 0.8 g/kg is the intake at which nitrogen balance is not negative in healthy weight-stable adults — a floor for deficiency prevention, not an optimum, and derived in a population that is not in a deficit. In a substantial energy deficit, protein requirement rises because amino acids are being oxidised for energy and because muscle protein synthesis is blunted. The literature on preserving lean mass during weight loss lands around 1.4 to 2.0 g/kg of reference body weight, which is roughly two to two and a half times the RDA.

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james_edin
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Apr 5, 2025 at 11:51 PM#5
TrialNerd_Beth said:
On a suppressed appetite the winning strategy is protein density per unit of volume, not per calorie.

Right, and one flattering data point from a group buy is not consistency. Consistency means separate batches, separately commissioned, over months.

24 19bbq_ray_KC, oliver_london, tane_welly and 21 others
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